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ea0011p874 | Thyroid | ECE2006

Demethylating treatment with azacytidine induces retinoic acid receptor RAR beta expression in human thyroid cancer cells

Miasaki FY , Vivaldi A , Ciampi R , Agate L , Cosci B , Piampiani P , Romei C , Pinchera A , Elisei R

We previously found that two cell lines (ARO and FRO) derived from anaplastic thyroid cancer and one (TT) deriving from medullary thyroid cancer did not respond to the retinoic acid (RA) treatment. We supposed that it was related to the lack of the RA receptor RAR beta mRNA expression. It has been suggested that the promoter methylation was one possible cause of loss of RAR beta expression.We analyzed the methylation status of RAR beta promoter in ARO, F...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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